Authors: Ashwini Angadi, Adarsh GS, Janaki R Torvi, Preeti V Kulkarni, Chetan Savant, Venkatrao H Kulkani
Abstract: COVID-19 vaccination has been a major public health intervention, significantly decreasing the incidence of severe infection, hospitalization, and death caused by SARS-CoV-2. The safety of currently authorized vaccines has been confirmed through extensive clinical trials and post-marketing surveillance. However, uncommon cardiovascular complications, including myocarditis and pericarditis, have been identified in a small number of vaccinated individuals, especially after administration of mRNA-based vaccines. In very rare situations, vaccine-associated myocarditis can progress to serious cardiac complications such as arrhythmias, impaired ventricular function, and, in exceptional cases, cardiac arrest. This review provides an overview of the available literature on cardiac arrest occurring after COVID-19 vaccination, focusing on potential pathophysiological mechanisms, clinical presentation, diagnostic evaluation, treatment strategies, and patient outcomes.

