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A Comprehensive Review Of Schiff Base Transition Metal Complexes: Synthetic Strategies, Structural Insights, And Biological Applications
Authors: Niranjan Kumar Mandal, Ranjan Kumar
Abstract: Schiff base transition metal complexes have emerged as a pivotal class of compounds in coordination chemistry due to their structural diversity, facile synthesis, and broad-spectrum biological activities. This review critically compiles and analyzes literature from 2000 to 2013, emphasizing synthetic methodologies, coordination behavior, and characterization techniques of Schiff base ligands and their complexes with transition metals. Particular attention is given to their promising applications in antimicrobial, antioxidant, anticancer, and catalytic domains. The role of the azomethine (-C=N-) functional group in ligand-metal binding and its impact on physicochemical properties is discussed in detail. Advances in understanding structure-activity relationships highlight how metal ion identity and ligand substituents influence bioactivity and selectivity. Challenges such as limited substrate scope and stability issues are also addressed, alongside prospects for future research involving novel Schiff base frameworks and sustainable synthesis routes. This comprehensive overview serves as an essential resource for scientists exploring Schiff base complexes in bioinorganic and medicinal chemistry.
DOI: https://doi.org/10.5281/zenodo.17157634
A Review On Schiff Base Metal Complexes: Synthesis, Characterization, And Applications
Authors: Ranjan Kumar, Niranjan Kumar Mandal
Abstract: Schiff base metal complexes have garnered significant attention in coordination chemistry due to their diverse structural features, catalytic properties, and biological activities. These complexes, synthesized via the condensation of primary amines with carbonyl compounds (e.g., salicylaldehyde, acetylacetone), form stable chelates with transition metals (e.g., Cu(II), Ni(II), Co(II), Zn(II)), exhibiting a wide range of coordination geometries (e.g., square planar, tetrahedral, octahedral). Their structural adaptability allows for tailored electronic environments, making them excellent candidates for catalytic processes such as asymmetric synthesis, C–C coupling, and oxidation reactions. Additionally, their interactions with biological macromolecules (e.g., DNA, proteins) have spurred interest in their use as antimicrobial, anticancer, and diagnostic agents. This review highlights the synthesis (e.g., template methods, solvent-free routes), characterization techniques (e.g., UV-Vis, IR, XRD, EPR), and applications of Schiff base metal complexes, emphasizing their relevance in medicinal chemistry (e.g., bioinorganic drug design), catalysis (e.g., industrial and green chemistry), and material science (e.g., luminescent materials, MOFs). By consolidating key findings from the literature before 2014, this work provides a comprehensive understanding of these versatile compounds, identifying gaps in current knowledge and suggesting future research avenues for optimizing their functional utility.
DOI: https://doi.org/10.5281/zenodo.17157735
Published by: vikaspatanker
