Authors: Vijaykumar Kale, Sumit Tamhankar, Shubham Chavan, Mahesh Thakare, Assistant Professor Vaibhav Narwade
Abstract: Inflammation is a natural protective response of the body against harmful stimuli such as infection, injury, toxins, and tissue damage. Although it plays an important role in healing and defense mechanisms, prolonged or chronic inflammation may lead to severe tissue damage and various disease conditions. Conventional anti-inflammatory drugs such as NSAIDs and corticosteroids are widely used for the management of inflammation; however, their long-term use is associated with several adverse effects including gastric irritation, renal toxicity, and cardiovascular complications. Due to these limitations, there is an increasing demand for safe, effective, and natural alternatives in the form of herbal formulations. The present study focuses on the formulation and evaluation of a herbal anti-inflammatory oil using Annona reticulata leaves extract along with turmeric, ginger, sesame oil, eucalyptus oil, mentha piperita oil, and vitamin E. Annona reticulata is rich in bioactive phytoconstituents such as flavonoids, alkaloids, tannins, and phenolic compounds which contribute to its anti-inflammatory and antioxidant activities. Turmeric provides curcumin, while ginger contains gingerols and shogaols, both of which are known for their strong anti-inflammatory properties. The essential oils included in the formulation enhance skin penetration, provide soothing effects, and improve overall therapeutic action. The formulated herbal oil was evaluated for various physicochemical parameters such as appearance, odor, pH, viscosity, spreadability, homogeneity, skin irritation, and stability. The results indicated that the formulation was stable, safe for topical application, and showed satisfactory characteristics. The synergistic effect of all herbal ingredients may contribute to effective reduction of inflammation with minimal side effects. Hence, the developed herbal oil formulation can be considered a promising, safe, and economical alternative for the management of inflammatory conditions.{1}
DOI: http://doi.org/
