Authors: Ms. Meenal Maan, Er. Rajdeep Saharawat, Muskan,, Dr. Vinit Kumar Sharma
Abstract: Proteins must fold into specific three-dimensional structures to function correctly. Errors in protein folding—misfolding—can lead to aggregation and are associated with several degenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. This review explores the molecular mechanisms of protein folding and misfolding, the cellular quality control systems managing these processes, and the pathogenesis of misfolding-related disorders. We also discuss therapeutic approaches aimed at correcting misfolding or enhancing proteostasis.
DOI: https://doi.org/10.5281/zenodo.16407753
