Authors: P. Kothari
Abstract: The challenge of managing wounds after surgery, especially following tumour removal, remains a key issue in clinical practice. This requires materials that can control the growth of remaining cancer cells while also encouraging the quick healing of soft tissues. In this study, we present the creation and testing of a new type of bioactive glass (BG) that includes Gallium (Ga) and Copper (Cu). This material is designed to help with wound healing. The base of this glass is made from a mixture of silicon dioxide, calcium oxide, sodium oxide, and phosphorus pentoxide. It was modified with varying amounts of gallium oxide and copper oxide (1–3 mol%) using a sol-gel method. The structure and properties of this glass were studied using X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, and UV-Vis-NIR spectroscopy to understand its network structure and optical behaviour. In vitro tests showed that this glass can form a layer of hydroxyapatite in simulated body fluid, indicating its bioactivity. Biological tests revealed that the Ga-doped glasses significantly reduced the survival of cancer cells, while the Cu-doped versions encouraged the growth of skin cells and promoted blood vessel formation. These results suggest that Ga and Cu co-doped BGs are a promising material for treating wounds in cancer patients.
DOI: http://doi.org/
