Authors: K. Amrutha Varshini, Gaddam Jancy, B. Manogna, B. Trisha, Mushti. Ankitha, Nunsavath Shanthi, Someshwar Komati, Dr. Someshwar Komati
Abstract: Nanoparticulate drug delivery systems have gained considerable attention for improving the therapeutic efficacy of poorly soluble anticancer drugs through controlled and targeted delivery. The present study aimed to formulate and characterize Docetaxel-loaded nanoparticles using Poly(lactic-co-glycolic acid) (PLGA) as a biodegradable carrier polymer. Nanoparticles were prepared by nanoprecipitation using optimized drug-to-polymer ratio and stabilizer concentration. The formulations were evaluated for particle size, zeta potential, entrapment efficiency, drug loading, and in-vitro drug release. FT-IR spectroscopy confirmed compatibility between drug and polymer, while zeta potential analysis indicated good colloidal stability. In-vitro release studies demonstrated sustained release of Docetaxel over an extended period. Kinetic analysis using zero-order, first-order, Higuchi, and Korsmeyer–Peppas models suggested a controlled drug release pattern predominantly governed by diffusion. The findings indicate that PLGA-based Docetaxel nanoparticles are a promising approach for targeted anticancer drug delivery with potential to enhance therapeutic efficacy and reduce systemic toxicity. Further in-vivo studies are recommended to confirm clinical applicability.
DOI: https://doi.org/10.5281/zenodo.20443596
