Authors: Janaki Ramarao Kasa, Dr. Chitra Gupta
Abstract: Due to their straightforwardness in synthesis, controllable electronic properties, high coordination abilities, and extensive biological importance, Schiff base derivatives concentrate greater importance and expertise in the research of organic and medicinal chemistry. The present study article surveys literature up to January 2016 so as to examine the impact of trends in functionalization on the chemical behaviour and medical uses of Schiff base antecedents. The research design used in the study is structured secondary research with the 60 peer-reviewed references published up to the beginning of the year 2016. The coding of these articles was by year of publication, structural classification, functional group modification, the ability to form metal-complex, biological use, and profile of activity reported. This was to identify the dominant research themes, gauge the major research treatment and interpretive uses, and to determine whether structural functionalization and metal coordination accepted superior performance. It has been disclosed that since 2010 and 2015, there was an increase in the number of studies published on Schiff bases, along with the most widespread types of use in the field were antimicrobial, anticancer, antioxidant, enzyme inhibitory, and chemosensing purposes. Schiff bases based on heteroaryl, quinoline, quinazoline, isatin, triazole and coumarin were particularly noticeable. Metal-complexed Schiff bases were found to be more commonly linked with DNA interaction, cytotoxicity and redox-based activity whereas metal free versions were more common in antimicrobial and enzyme-inhibition studies. Electron-withdrawing groups, incorporation of heterocyclic rings and the use of donor atoms like nitrogen and oxygen were always used to enhance reactivity and biological potential. The paper concludes that functionalized Schiff base derivatives were widely used as molecular platforms with twist before 2016 in selecting synthetic organic chemistry and coordination chemistry and medicinal chemistry, and the development of multifunctional therapeutics, molecular probes and catalytic systems used after 2016 builds off their earlier development.
