Exploring the Role of Microglia Activation in Alzheimer’s Disease and Parkinson’s Disease
Authors:-Tamaradoubrah Favour Melex, Akuroseokike G Babbo
Abstract-Microglia, the principal immune cells within the central nervous system (CNS), are essential for maintaining neuronal homeostasis. Nonetheless, the chronic activation of microglia has been associated with the development of neurodegenerative diseases, notably Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). This review investigates the mechanisms underlying microglial activation, the dual functions of microglia in neuroprotection and neurotoxicity, and the implications for therapeutic strategies. By examining contemporary research, we aim to clarify the molecular pathways that link microglial activation to the progression of these diseases and identify potential approaches for modulating microglial responses to alleviate neurodegeneration.
